Article

Acceleration of genome replication uncovered by single-cell nascent DNA sequencing

2022-12-14

Abstract excerpt

In a human cell thousands of replication forks simultaneously coordinate the duplication of the entire genome. The rate at which this process occurs, might depend on the epigenetic state of the genome and vary between, or even within, cell types. To accurately measure DNA replication speeds, we developed a technology to detect recently replicated DNA using single-cell sequencing. Replication speed is not constant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c18f36c0-9f1f-50a0-80d8-a2be13afc219
DOI: 10.1101/2022.12.13.520365

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Acceleration of genome replication uncovered by single-cell nascent DNA sequencingDOI 10.1101/2022.12.13.520365Read

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read

Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation SequencingSemantic proximity Read

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read

Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies <i>MCM10</i> as a novel regulator of the replication programSemantic proximity Read

Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication MappingSemantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read

Embryonic genome instability upon DNA replication timing program emergenceSemantic proximity Read

DNA replication timing reveals genome-wide features of transcription and fragilitySemantic proximity Read

Delayed DNA replication in haploid human embryonic stem cellsSemantic proximity Read

DNA replication stress: from molecular mechanisms to human diseaseSemantic proximity Read