Article

Unravelling the Cell-Penetrating Potential of Endogenous Opioid Neuropeptide Dynorphin A through Computational Dissection of Membrane Disruption Principles

2024-03-07

Abstract excerpt

<title>Abstract</title> Dynorphins are endogenous neuropeptides that function as opioids. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. Previous studies have suggested that Dynorphin A (DynA) and its clinical variants (L5S, R6W, and R9C) mediate some pathogenic actions through formation of transient pores in lipid domains of...

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Literature Corpus work: 1e9aefbc-30e8-58df-962f-79fa58015920
DOI: 10.21203/rs.3.rs-3910635/v1

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