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Article

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5.

Protein science : a publication of the Protein Society - 1 Sept 2025

Berselli Alessandro, Alberini Giulio, Cerioni Linda, Benfenati Fabio, Maragliano Luca

Abstract excerpt

In the blood-brain barrier (BBB), endothelial cells are joined by tight junctions (TJs), multi-protein assemblies that seal the paracellular space and restrict molecular transport. Among the BBB TJ proteins, Claudin-5 (Cldn15) is the most abundant one. Structural models for claudin complexes, first introduced for channel-forming, selectively permeable claudins, comprise protomers arranged to form paracellular...

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PMID: 40862374
DOI: 10.1002/pro.70271
PMCID: PMC12381782

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