Article
Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nature structural & molecular biology - 1 Jul 2020
Zheng Xiangdong, Fu Ziao, Su Deyuan, Zhang Yuebin, Li Minghui, Pan Yaping, Li Huan, Li Shufang, Grassucci Robert A, Ren Zhenning, Hu Zhengshan, Li Xueming, Zhou Ming, Li Guohui, Frank Joachim, Yang Jian
Abstract excerpt
Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We report both closed- and open-state atomic cryo-EM structures of a full-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nanodiscs....
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