Article

Sub-dalton Discrimination of Citrullination by a Semi-rationally Designed Aerolysin Nanopore

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>Citrullination, a post-translational modification (PTM) with a sub-dalton mass shift of only + 0.984 Da, plays critical roles in epigenetics and autoimmunity and is a hallmark of several inflammatory diseases, but remains a particularly long-standing challenge to resolve by conventional proteomics. Here we present Physical Interaction Transduction on Nanopores (PIToN), a semi-rational m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b97ef33e-2ed6-5aae-b871-4abe17fd629a
DOI: 10.21203/rs.3.rs-9607376/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sub-dalton Discrimination of Citrullination by a Semi-rationally Designed Aerolysin NanoporeDOI 10.21203/rs.3.rs-9607376/v1Read

Charge-based fingerprinting of unlabeled full-length proteins using an aerolysin nanoporeSemantic proximity Read

Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores.Semantic proximity Read

Comparative study of nanopore phenylalanine clamp variants reveals unique peptide biosensing and classification propertiesSemantic proximity Read

Deep learning-assisted single-molecule detection of protein post-translational modifications with a biological nanoporeSemantic proximity Read

Dynamic gating by ϕ-clamp loop controls peptide translocation through the anthrax toxin nanopore.Semantic proximity Read

Single-Molecule Proteomics via a Dynamic Translocase and Physics-Informed Machine LearningSemantic proximity Read

A quantitative and site-specific atlas of the in vivo citrullinome reveals widespread existence of citrullinationSemantic proximity Read

Citrullination of Proteins: A Common Post-Translational Modification Pathway Induced by Different Nanoparticles<i>In Vitro</i>and<i>In Vivo</i>Semantic proximity Read

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive argininesSemantic proximity Read

The soluble N-termini of mechanosensitive ion channels MSL8, MSL9, and MSL10 are environmentally sensitive intrinsically disordered regions with distinct biophysical characteristicsSemantic proximity Read

MspA Porin as a Local Nanopore Probe for Membrane-bound ProteinsSemantic proximity Read

A Generalizable Nanopore Sensor for Highly Specific Protein Detection at Single-Molecule PrecisionSemantic proximity Read