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Novel single molecule imaging approaches reveal structure-function alterations to the nuclear pore complex in early C9ORF72 -associated TDP-43 proteinopathy

2026-02-18

Abstract excerpt

Nucleocytoplasmic transport through the nuclear pore complex is essential for the maintenance of cellular homeostasis by regulating the movement of molecules between the nucleus and the cytoplasm. This process becomes dysfunctional in many diseases but has been particularly implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) linked to the C9ORF72 mutation and associated aberrantly...

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Literature Corpus work: e10d616b-c422-5ca9-8014-a2929f3e97a5
DOI: 10.64898/2026.02.17.706337

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Novel single molecule imaging approaches reveal structure-function alterations to the nuclear pore complex in early C9ORF72 -associated TDP-43 proteinopathyDOI 10.64898/2026.02.17.706337Read

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Novel single molecule imaging approaches reveal structure-function alterations to the nuclear pore complex in early <i>C9ORF72</i> -associated TDP-43 proteinopathy

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