Article

Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na <sub>V</sub> 1.7 Channel

2023-03-01

Abstract excerpt

Human voltage-gated sodium (hNa V ) channels are responsible for initiating and propagating action potentials in excitable cells and mutations have been associated with numerous cardiac and neurological disorders. hNa V 1.7 channels are expressed in peripheral neurons and are promising targets for pain therapy. The tarantula venom peptide protoxin-2 (PTx2) has high selectivity for hNa V 1.7 and serves as a valu...

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Literature Corpus work: 8a3eb7b8-034e-5b02-9947-fa45acf998f1
DOI: 10.1101/2023.02.27.530360

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