Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In-silico screening of missense nsSNPs in Delta-opioid receptor protein and their restoring tendency on MCRT interaction; focusing on dynamic nature.

International journal of biological macromolecules - 1 Aug 2024

Simon Jerine Peter, Dong Shouliang

Abstract excerpt

Delta-opioid receptor protein (OPRD1) is one of the potential targets for treating pain. The presently available opioid agonists are known to cause unnecessary side effects. To discover a novel opioid agonist, our research group has synthesized a chimeric peptide MCRT and proved its potential activity through in vivo analysis. Non-synonymous SNPs (nsSNPs) missense mutations affect the functionality and stability...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Mutation, Missense

Share to Oligopeptides

Share to Protein Binding

Share to Receptors, Opioid, delta

Source

Identifiers

PMID: 38977046
DOI: 10.1016/j.ijbiomac.2024.133710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In-silico screening of missense nsSNPs in Delta-opioid receptor protein and their restoring tendency on MCRT interaction; focusing on dynamic nature.PMID 38977046Read ↗

Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways.Semantic proximity Read ↗

Unraveling the function and structure impact of deleterious missense SNPs in the human OX1R receptor by computational analysis.Semantic proximity Read ↗

Computational identification of pathogenic associated nsSNPs and its structural impact in UROD gene: a molecular dynamics approach.Semantic proximity Read ↗

Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants.Semantic proximity Read ↗

Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F.Semantic proximity Read ↗

Recent Applications of In Silico Approaches for Studying Receptor Mutations Associated with Human Pathologies.Semantic proximity Read ↗

Assessment of structurally and functionally high-risk nsSNPs impacts on human bone morphogenetic protein receptor type IA (BMPR1A) by computational approachSemantic proximity Read ↗

Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as modelSemantic proximity Read ↗

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.Semantic proximity Read ↗

Computational identification and analysis of deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in the human POR gene: a structural and functional impact.Semantic proximity Read ↗

Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor.Semantic proximity Read ↗

A comprehensive in silico investigation into the nsSNPs of Drd2 gene predicts significant functional consequences in dopamine signaling and pharmacotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.