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A claudin5-binding peptide enhances the permeability of the blood-brain-barrier

2024-04-30

Abstract excerpt

<h4>ABSTRACT</h4> The blood-brain barrier (BBB) is essential to maintain brain homeostasis and healthy conditions but it also prevents drugs from reaching brain cells. In the BBB, tight junctions (TJs) are multi-protein complexes located at the interface between adjacent brain endothelial cells that regulate paracellular diffusion and claudin-5 (CLDN5) is the major component of the TJ portfolio, playing a pivotal...

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Literature Corpus work
43774eee-5397-5e85-922d-333b7eb8ab22
DOI
10.1101/2024.04.29.591687
Open publication

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A claudin5-binding peptide enhances the permeability of the blood-brain-barrierDOI 10.1101/2024.04.29.591687
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