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Electrostatic control of membrane disruption and amorphous coaggregation by dynorphin A variants.

Biochemical and biophysical research communications - 20 Aug 2026

Habibnia Mohsen, Catalina-Hernandez Eric, Barnadas-Rodríguez Ramon, Peralvarez-Marin Alex

Abstract excerpt

Dynorphin A is a highly cationic neuropeptide that exhibits membrane activity beyond its canonical opioid receptor signaling. Here, we investigate how sequence variants of Dynorphin A associated with spinocerebellar ataxia type 23 modulate membrane disruption and aggregation behavior. Using computational electrophysiology simulations combined with liposome leakage and fluorescence-based aggregation assays, we...

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Amino Acid Sequence
Cell Membrane
Lipid Bilayers
Liposomes
Molecular Dynamics Simulation

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PMID: 42235331
DOI: 10.1016/j.bbrc.2026.154059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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