Article

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5

2025-01-29

Abstract excerpt

<h4>ABSTRACT</h4> In the blood-brain barrier (BBB), endothelial cells are joined together by multi-protein assemblies called tight junctions (TJs), which seal the paracellular space and restrict the passage of substances. Among the proteins forming BBB TJs, Claudin-5 (Cldn5) is the most abundant one. Structural models for complexes of Cldn5 and other claudins have been proposed and assessed via experimental and c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f007ec7-f90b-595b-b1ef-ac11e7c2ddd0
DOI: 10.1101/2025.01.29.635460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5DOI 10.1101/2025.01.29.635460Read

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5.Semantic proximity Read

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics SimulationsSemantic proximity Read

Molecular dynamics analyses of CLDN15 pore size and charge selectivitySemantic proximity Read

Molecular dynamics analyses of CLDN15 pore size and charge selectivity.Semantic proximity Read

A claudin5-binding peptide enhances the permeability of the blood-brain-barrierSemantic proximity Read

Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia.Semantic proximity Read

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner.Semantic proximity Read

Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments.Semantic proximity Read

Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.Semantic proximity Read

Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.Semantic proximity Read

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s DiseaseSemantic proximity Read

The region‐selective regulation of endothelial claudin‐5 expression and signaling in brain health and disordersSemantic proximity Read