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Article

Membrane interaction of disease-related dynorphin A variants.

Biochemistry - 18 Jun 2013

Björnerås Johannes, Gräslund Astrid, Mäler Lena

Abstract excerpt

The membrane interaction properties of two single-residue variants, R6W and L5S, of the 17-amino acid neuropeptide dynorphin A (DynA) were studied by circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy. Corresponding gene mutations have recently been discovered in humans and causatively linked to a neurodegenerative disorder. The peptides were investigated in buffer and in isotropic...

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PMID: 23705820
DOI: 10.1021/bi4004205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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