Efficient Selection of DNA Aptamers with High Affinity and Specificity to GPCRs via Functional Extracellular Vesicles

Abstract excerpt

<title>Abstract</title> <p> Nucleic acid aptamers are promising new-generation experimental and therapeutic drugs for uncharacterized biomolecules and intractable diseases. However, efficient aptamer selection remains challenging. We present a novel functional selection method termed extracellular vesicle (EV)-SELEX that efficiently selects DNA aptamers for G protein-coupled proteins (GPCRs), a major class of dr...

Topics

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• Advanced biosensing and bioanalysis techniques
• Chemical Synthesis and Analysis
• Monoclonal and Polyclonal Antibodies Research
• Receptor Mechanisms and Signaling
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• RNA Research and Splicing
• SARS-CoV-2 detection and testing

Identifiers and source

Literature Corpus work

d2df4a01-cdbf-50e8-8c4e-75aa5357c00d

DOI

10.21203/rs.3.rs-6638225/v1