Article

Bioengineered recombinant kisspeptins with extended half-life exhibit novel peripheral function in a large-animal model

2026-02-06

Abstract excerpt

Kisspeptins are the small peptide products encoded by the KISS1 gene and physiologically exist in various isoforms of variable length. They are the central regulators of reproduction, being a prominent driver of GnRH hormone secretion. Additionally, they have emerged as an important peripheral therapeutic target for many metabolic diseases like diabetes, obesity, and polycystic ovary syndrome (PCOS). Despite their...

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Literature Corpus work: c3649f8d-c9a2-5018-9cbe-8383f396df8b
DOI: 10.64898/2026.02.04.703727

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