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Article

CRISPR PERSIST-On enables heritable and fine-tunable human gene activation

2024-04-26

Abstract excerpt

Current technologies for upregulation of endogenous genes use targeted artificial transcriptional activators but stable gene activation requires persistent expression of these synthetic factors. Although general “hit-and-run” strategies exist for inducing long-term silencing of endogenous genes using targeted artificial transcriptional repressors, to our knowledge no equivalent approach for gene activation has bee...

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Literature Corpus work
adbd2d42-889f-5cb6-a586-9e9e13f873a2
DOI
10.1101/2024.04.26.590475
Open publication

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CRISPR PERSIST-On enables heritable and fine-tunable human gene activationDOI 10.1101/2024.04.26.590475
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