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Repurposing the TIGR-Tas system for programmable transcription activation

2026-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Programmable transcription activators are central to functional genomics, gene therapy, and synthetic biology. However, application of the most versatile CRISPR activators (CRISPRa) is hampered by the bulky size and compact CRISPR systems are constrained by the requirement of long protospacer adjacent motifs (PAMs). To address these limitations, we repurposed the TIGR-Tas RNA-guided DNA-targetin...

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Literature Corpus work
b675d882-eac2-5cbc-afe0-982e54b755fe
DOI
10.64898/2026.07.30.739400
Open publication

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Repurposing the TIGR-Tas system for programmable transcription activationDOI 10.64898/2026.07.30.739400
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