Article

Structure-guided discovery and engineering of miniature CRISPR-Cas12m for epigenome editing

2026-03-28

Abstract excerpt

CRISPR-based epigenome editing represents a programmable strategy to precisely modulate gene expression, holding immense promise for therapeutic applications. However, the large size of the dCas proteins substantially impedes the delivery via adeno-associated virus (AAV) vectors. Here, through iterative bioinformatics analysis, structure-guided predictions, and functional assays, we identified and characterized Pm...

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Identifiers and source

Literature Corpus work: 5633b19a-591c-5d3b-97f8-083eab1de952
DOI: 10.64898/2026.03.26.714355

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