Article

All-in-one, Cas13d-based cell-specific gene knockdown system for zebrafish

2026-04-27

Abstract excerpt

Cell type-specific genetic manipulation is essential for dissecting neural circuits and glial biology in vivo ; however, methods for achieving and validating cell-specific gene knockdown in zebrafish remain limited. Here, we introduce a CRISPR-Cas13d-based mRNA knockdown platform for zebrafish that leverages RNA targeting, rather than DNA editing, to enable efficient and flexible perturbation of gene function in...

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Literature Corpus work: 1cfc664b-a8ee-5faa-bcab-f63478c6aea6
DOI: 10.64898/2026.04.23.720501

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