Article

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

2026-07-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryonic stem cells (hESCs) serve as important models for developmental and regenerative research, the application of Cas7-11 in these mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3434675-c5fe-5f99-bd17-9b7e7fceb7b6
DOI: 10.21203/rs.3.rs-9395933/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cellsDOI 10.21203/rs.3.rs-9395933/v1Read

Generation of Targeted Mutations in Zebrafish Using the CRISPR/Cas System.Semantic proximity Read

Off-target effects in CRISPR/Cas9 gene editingSemantic proximity Read

Enhance genome editing efficiency and specificity by a quick CRISPR/Cas9 systemSemantic proximity Read

New Developments in CRISPR/Cas-based Functional Genomics and their Implications for Research Using Zebrafish.Semantic proximity Read

CRISPR-Cas9 induces large structural variants at on-target and off-target sites <i>in vivo</i> that segregate across generationsSemantic proximity Read

Massively Targeted Evaluation of Therapeutic CRISPR Off-Targets in CellsSemantic proximity Read

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effectSemantic proximity Read

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbationSemantic proximity Read

Comparison of Various Nuclear Localization Signal-Fused Cas9 Proteins and Cas9 mRNA for Genome Editing in Zebrafish.Semantic proximity Read

High‐throughput screens in mammalian cells using the CRISPR‐Cas9 systemSemantic proximity Read

Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicingSemantic proximity Read

Detection of precisely edited CRISPR/Cas9 alleles through co-introduced restriction-fragment length polymorphismsSemantic proximity Read