Article

RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells

2021-11-30

Abstract excerpt

<h4>ABSTRACT</h4> While single-cell sequencing has allowed rapid identification of novel cell types or states and associated RNA markers, functional studies remain challenging due to the lack of tools that are able to target specific cells based on these markers. Here we show that targeting a single marker RNA with CRISPR/RfxCas13d led to collateral transcriptome destruction in human cells, which can be harnessed...

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Literature Corpus work: a2f3b252-f012-53b7-9823-821e06c5c104
DOI: 10.1101/2021.11.30.470032

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