Article
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.
Nature structural & molecular biology - 1 Mar 2017
Borensztein Maud, Syx Laurène, Ancelin Katia, Diabangouaya Patricia, Picard Christel, Liu Tao, Liang Jun-Bin, Vassilev Ivaylo, Galupa Rafael, Servant Nicolas, Barillot Emmanuel, Surani Azim, Chen Chong-Jian, Heard Edith
Abstract excerpt
The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse preimplantation female embryos and mediates transcriptional silencing of that chromosome. In females, absence of Xist leads to postimplantation lethality. Here, through single-cell RNA sequencing of early preimplantation mouse embryos, we found that the initiation of imprinted X-chromosome inactivation absolutely requires Xist....
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