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Article

Elastic dosage compensation by X-chromosome upregulation.

Nature communications - 6 Apr 2022

Lentini Antonio, Cheng Huaitao, Noble J C, Papanicolaou Natali, Coucoravas Christos, Andrews Nathanael, Deng Qiaolin, Enge Martin, Reinius Björn

Abstract excerpt

X-chromosome inactivation and X-upregulation are the fundamental modes of chromosome-wide gene regulation that collectively achieve dosage compensation in mammals, but the regulatory link between the two remains elusive and the X-upregulation dynamics are unknown. Here, we use allele-resolved single-cell RNA-seq combined with chromatin accessibility profiling and finely dissect their separate effects on RNA...

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Share to Alleles
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35388014
DOI: 10.1038/s41467-022-29414-1
PMCID: PMC8987076

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