Article

HyperCas12a enables multiplexed CRISPRi screens

2024-07-09

Abstract excerpt

Interactions between multiple genes or cis-regulatory elements (CREs) underlie a wide range of biological processes in both health and disease. High-throughput screens using dCas9 fused to epigenome editing domains have allowed researchers to assess the impact of activation or repression of both coding and non-coding genomic regions on a phenotype of interest, but assessment of genetic interactions between those e...

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Literature Corpus work: 1c880022-b872-5002-8c0a-367142d58d2d
DOI: 10.1101/2024.07.08.602263

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