Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of diverse Cas9 orthologs for genome and epigenome editing

12 Mar 2025

Abstract excerpt

CRISPR-Cas9 systems have revolutionized biotechnology, creating diverse new opportunities for biomedical research and therapeutic genome and epigenome editing. Despite the abundance of bacterial CRISPR-Cas9 systems, relatively few are effective in human cells, limiting the overall potential of CRISPR technology. To expand the CRISPR-Cas toolbox, we characterized a set of type II CRISPR-Cas9 systems from select...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Insect symbiosis and bacterial influences
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40073054
DOI: 10.1073/pnas.2417674122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of diverse Cas9 orthologs for genome and epigenome editingPMID 40073054Read ↗

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering ToolboxSemantic proximity Read ↗

CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomesSemantic proximity Read ↗

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.Semantic proximity Read ↗

Application of CRISPR/Cas9 for biomedical discoveriesSemantic proximity Read ↗

PpCas9 from Pasteurella pneumotropica — a compact Type II-C Cas9 ortholog active in human cellsSemantic proximity Read ↗

Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discoverySemantic proximity Read ↗

Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs.Semantic proximity Read ↗

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants.Semantic proximity Read ↗

Improving FnCas12a genome editing by exonuclease fusionSemantic proximity Read ↗

Harnessing CRISPR-Cas systems for bacterial genome editing.Semantic proximity Read ↗

Development and Application of CRISPR-Cas Based ToolsSemantic proximity Read ↗

CRISPR-Cas Biology and Its Application to Infectious DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.