Article

Genetic and epigenetic control of gene expression by CRISPR–Cas systems

2017-05-25

Abstract excerpt

The discovery and adaption of bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems has revolutionized the way researchers edit genomes. Engineering of catalytically inactivated Cas variants (nuclease-deficient or nuclease-deactivated [dCas]) combined with transcriptional repressors, activators, or epigenetic modifiers enable sequence-specific regulation of ge...

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Literature Corpus work: 67d2d5cc-396d-56cc-a999-282ebe8266d4
DOI: 10.12688/f1000research.11113.1

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