HyperdCas12a-Based Multiplexed Genetic Regulation in <i>Candida albicans</i>

Abstract excerpt

Complex microbial phenotypes involve the combined activity of diverse gene regulatory networks. However, the majority of reverse genetics approaches in microbial pathogenesis research have focused on single-gene perturbation studies, in part due to the lack of available genetic tools in many pathogens. Developing enhanced versions of CRISPR-Cas platforms holds significant promise for improving the scalability of m...

Topics

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• Antifungal resistance and susceptibility
• CRISPR and Genetic Engineering
• Fungal Infections and Studies
• Nematode management and characterization studies
• Parasitic Diseases Research and Treatment
• Plant-Microbe Interactions and Immunity
• Plant tissue culture and regeneration
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

3e0bbd32-0914-5b4a-b461-3582b2b5894f

DOI

10.1101/2025.10.20.683421