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CRISPR-Based Epigenome Editing: Mechanisms and Applications

1 Nov 2023

Abstract excerpt

Epigenomic anomalies contribute significantly to the development of numerous human disorders. The development of epigenetic research tools is essential for understanding how epigenetic marks contribute to gene expression. A gene-editing technique known as CRISPR (clustered regularly interspaced short palindromic repeats) typically targets a particular DNA sequence using a guide RNA (gRNA). CRISPR/Cas9 technology...

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PMID: 37990877
DOI: 10.2217/epi-2023-0281

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