Article

Paired CRISPR screens to map gene regulation in <i>cis</i> and <i>trans</i>

2024-11-27

Abstract excerpt

<h4>Summary</h4> Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discovery of either cis -regulatory elements (CREs) or trans -acting factors. Here, we develop a scalable approach that pairs cis - and trans -regulatory CRISPR screens to systematically dissect how the key immune checkpoint PD-L1 is regulated. In human pancreatic ductal adenocarcinoma (PDAC) cells,...

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Literature Corpus work: 747bc697-5be7-530e-acf4-a4c3928cb5b8
DOI: 10.1101/2024.11.27.625752

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