Article

Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation – ‘MR Fish’

2024-07-11

Abstract excerpt

We propose an extension of the Mendelian randomisation (MR) paradigm (‘MR-Fish’) in which the confounded disease association of an index protein (‘the bait’) is harnessed to identify the causal role of different proteins (‘the catch’) for the same disease. Using C-reactive protein (CRP) as the bait, cis -MR analyses refuted a causal relationship of CRP with a wide range of diseases that associate with CRP in obser...

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Literature Corpus work: 1bc4dfdc-3f5e-54b8-a54e-5dc08fcf83df
DOI: 10.1101/2024.07.11.24310200

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