Article
Genetic drug target validation using Mendelian randomization
2019-09-25
Abstract excerpt
Mendelian randomisation analysis has emerged as an important tool to elucidate the causal relevance of a range of environmental and biological risk factors for human disease. However, inference on cause is undermined if the genetic variants used to instrument a risk factor of interest also associate with other traits that open alternative pathways to the disease (horizontal pleiotropy). We show how the ‘no horizon...
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Identifiers and source
- Literature Corpus work
- a95bee19-35bb-5210-8a06-ee2d38c15b66
- DOI
- 10.1101/781039