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Article

A multivariable cis-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias.

Briefings in bioinformatics - 1 May 2025

Yang Yihe, Lorincz-Comi Noah, Li Mengxuan, Zhu Xiaofeng

Abstract excerpt

Multivariable cis-Mendelian randomization (cis-MVMR) has become an effective approach for identifying therapeutic targets that influence disease susceptibility. However, biases from invalid instruments, such as weak instruments and horizontal pleiotropy, remain unsolved. In this paper, we propose a new method called the cis-Mendelian randomization bias correction estimating equation (cis-MRBEE), which mitigates...

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Alzheimer Disease
Bias
APOC1 gene
TG gene
Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 40471990
DOI: 10.1093/bib/bbaf250
PMCID: PMC12140020

Genes

ANGPTL3
APOA1
APOC1
CR1
PCSK9
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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