Article

Mendelian randomization informs shared genetic etiology underlying exposure and outcome by interrogating correlated horizontal pleiotropy

2021-09-30

Abstract excerpt

<title>Abstract</title> <p>Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to study the causal effect of exposure on trait/disease using summary statistics from genome-wide association studies. Classic MR assumptions are violated when IVs are associated with unmeasured confounders, i.e., when correlated horizontal pleiotropy (CHP) arises. Such confounders could be a shared...

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Literature Corpus work: e2cfc277-eb1d-5818-87dc-67888bdd7fe1
DOI: 10.21203/rs.3.rs-860357/v1

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