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Article

Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology.

Nature communications - 30 Oct 2022

Cheng Qing, Zhang Xiao, Chen Lin S, Liu Jin

Abstract excerpt

Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to study the causal effect of exposure on outcome using summary statistics from genome-wide association studies. Classic MR assumptions are violated when IVs are associated with unmeasured confounders, i.e., when correlated horizontal pleiotropy (CHP) arises. Such confounders could be a shared gene or inter-connected pathways...

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Identifiers

PMID: 36310177
DOI: 10.1038/s41467-022-34164-1
PMCID: PMC9618026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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