Article

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

2019-05-10

Abstract excerpt

Target identification remains a crucial challenge in drug development. To enable unbiased detection of proteins and pathways that have a causal role in disease pathogenesis or progression, we propose proteome-by-phenome Mendelian Randomisation (P 2 MR). We first detected genetic variants associated with plasma concentration of 249 proteins. We then used 64 replicated variants in two-sample Mendelian Randomisation...

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Literature Corpus work: d56a4d67-503a-55e5-8ac0-c6e4238a1b66
DOI: 10.1101/631747

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