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Article

Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets

2024-10-21

Abstract excerpt

Circulating proteins influence disease risk and are valuable drug targets. To enhance the discovery of protein-phenotype associations and identify potential therapeutic targets across diverse populations, we conducted proteome-phenome-wide Mendelian randomization in three ancestries, followed by comprehensive sensitivity analyses. We tested the potential causal effects of up to 2,265 unique proteins on a curated l...

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Literature Corpus work
0d99c7c4-30cb-5f54-9b2c-7eb32fbc33ae
DOI
10.1101/2024.10.17.24315553
Open publication

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Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targetsDOI 10.1101/2024.10.17.24315553
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