Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The immunoproteome and multimorbidity: A Mendelian randomization study.

Science advances - 22 May 2026

Hukerikar Nikita, Hingorani Aroon D, Chopade Sandesh, Cupido Arjen J, Asselbergs Folkert W, Finan Chris, Schmidt A Floriaan

Abstract excerpt

Multimorbidity presents challenges for research and health care. We investigated how immune-proteins influence multiple diseases to identify shared mechanisms and therapeutic opportunities. Using eight large plasma proteome GWAS, we identified cis-acting variants for 151 immune-proteins and applied cis-Mendelian randomization to assess associations with 64 diseases and biomarkers. Protein-disease communities were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Proteome

Share to Proteomics

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42160433
DOI: 10.1126/sciadv.adz7117
PMCID: PMC13189124

Genes

APOE
CD163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The immunoproteome and multimorbidity: A Mendelian randomization study.PMID 42160433Read ↗

Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targetsSemantic proximity Read ↗

Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.Semantic proximity Read ↗

Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization.Semantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseasesSemantic proximity Read ↗

Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.Semantic proximity Read ↗

Uncovering bi-directional causal relationships between plasma proteins and psychiatric disorders: A proteome-wide study and directed network analysisSemantic proximity Read ↗

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read ↗

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseasesSemantic proximity Read ↗

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes.Semantic proximity Read ↗

Mendelian randomization for autoimmune diseases: exploring causal links and drug targets in plasma proteomeSemantic proximity Read ↗

A Mendelian randomization study identifies proteins involved in neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.