Article
Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.
Circulation - 19 Apr 2022
Henry Albert, Gordillo-Marañón María, Finan Chris, Schmidt Amand F, Ferreira João Pedro, Karra Ravi, Sundström Johan, Lind Lars, Ärnlöv Johan, Zannad Faiez, Mälarstig Anders, Hingorani Aroon D, Lumbers R Thomas
Abstract excerpt
BACKGROUND: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provides an opportunity to identify new therapeutic targets. METHODS: We investigated the observational and causal associations of 90 cardiovascular proteins, which were measured using affinity-based proteomic assays....
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