Article
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids.
Nature communications - 1 Oct 2020
van der Graaf Adriaan, Claringbould Annique, Rimbert Antoine, Westra Harm-Jan, Li Yang, Wijmenga Cisca, Sanna Serena
Abstract excerpt
Inference of causality between gene expression and complex traits using Mendelian randomization (MR) is confounded by pleiotropy and linkage disequilibrium (LD) of gene-expression quantitative trait loci (eQTL). Here, we propose an MR method, MR-link, that accounts for unobserved pleiotropy and LD by leveraging information from individual-level data, even when only one eQTL variant is present. In simulations,...
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