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Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.

Molecular genetics and genomics : MGG - 3 Aug 2026

Zhong Hua, Zhu Jingjing, Liu Shuai, Wong Hoi Tung Hilton, Zhang Yiqiang, Luu Hung N, Wu Qing, Wang Xuexia, Wu Lang

Abstract excerpt

Blood proteins may play causal roles in cardiovascular diseases (CVDs) such as heart failure (HF) and peripheral artery disease (PAD). Proteome-wide Mendelian randomization (MR) has been widely used to prioritize drug targets for CVD in European populations, but its application to non-European populations remains limited. We conducted a proteome-wide MR analysis to evaluate the potential causal effects of 2,922...

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Identifiers

PMID: 42545500
DOI: 10.1007/s00438-026-02458-4
PMCID: PMC13433639

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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