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Genotype-immunophenotype relationships in NPM1 -mutant AML clonal evolution uncovered by single cell multiomic analysis

2024-11-12

Abstract excerpt

Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing cannot fully capture AML clonal architecture or the clonal evolution that occurs as patients undergo therapy. To interrogate clonal evolution, we performed simultaneous single cell molecular profiling and immunophenotypi...

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Literature Corpus work: 180278cd-c936-5d6d-837f-ba84a556b32e
DOI: 10.1101/2024.11.11.623033

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Genotype-immunophenotype relationships in <i>NPM1</i> -mutant AML clonal evolution uncovered by single cell multiomic analysis

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