Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.

doi:10.1038/s41467-020-19119-8

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Article

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.

Nature communications - 21 Oct 2020

Morita Kiyomi, Wang Feng, Jahn Katharina, Hu Tianyuan, Tanaka Tomoyuki, Sasaki Yuya, Kuipers Jack, Loghavi Sanam, Wang Sa A, Yan Yuanqing, Furudate Ken, Matthews Jairo, Little Latasha, Gumbs Curtis, Zhang Jianhua, Song Xingzhi, Thompson Erika, Patel Keyur P, Bueso-Ramos Carlos E, DiNardo Courtney D, Ravandi Farhad, Jabbour Elias, Andreeff Michael, Cortes Jorge, Bhalla Kapil, Garcia-Manero Guillermo, Kantarjian Hagop, Konopleva Marina, Nakada Daisuke, Navin Nicholas, Beerenwinkel Niko, Futreal P Andrew, Takahashi Koichi

Abstract excerpt

Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection. Precise characterization of clonal architecture is essential to understand the evolutionary history of tumor development and its association with treatment resistance. Here, using a single-cell DNA sequencing, we report the clonal architecture and mutational histories of 123 acute myeloid leukemia (AML) patients. The...

Topics

Aged
Animals
Clonal Evolution
Cohort Studies
Female
Genetic Association Studies
Genomics
Heterografts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Humans

Leukemia, Myeloid, Acute

Male

Mice

Mice, Inbred NOD

Middle Aged

Models, Genetic

Mutation

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 33087716
DOI: 10.1038/s41467-020-19119-8
PMCID: PMC7577981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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