Article
Single-cell mutation analysis of clonal evolution in myeloid malignancies.
Nature - 1 Nov 2020
Miles Linde A, Bowman Robert L, Merlinsky Tiffany R, Csete Isabelle S, Ooi Aik T, Durruthy-Durruthy Robert, Bowman Michael, Famulare Christopher, Patel Minal A, Mendez Pedro, Ainali Chrysanthi, Demaree Benjamin, Delley Cyrille L, Abate Adam R, Manivannan Manimozhi, Sahu Sombeet, Goldberg Aaron D, Bolton Kelly L, Zehir Ahmet, Rampal Raajit, Carroll Martin P, Meyer Sara E, Viny Aaron D, Levine Ross L
Abstract excerpt
Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular profiling has suggested that mutations are acquired in a stepwise fashion: mutant genes with high variant allele frequencies appear early in leukaemogenesis, and mutations with lower variant allele frequencies are thought to be acquired...
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