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Article

Genetic heterogeneity and clonal evolution in acute myeloid leukemia.

Current opinion in hematology - 1 Jan 2021

Romer-Seibert Jennifer S, Meyer Sara E

Abstract excerpt

PURPOSE OF REVIEW: Clonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new advances in the understanding of genetic heterogeneity in AML using single-cell DNA-sequencing technology. RECENT FINDINGS: New genomics and immunologic discovery tools have provided single-cell resolution maps of the clonal architecture of AML. The use of...

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Share to Acute Myeloid Leukemia Research
Share to Clonal Evolution
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Leukemia, Myeloid, Acute

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Share to Sequence Analysis, RNA

Share to Single-Cell Analysis

Source

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Identifiers

PMID: 33186150
DOI: 10.1097/MOH.0000000000000626
PMCID: PMC7731048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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