Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting Clonal Heterogeneity in AML.

Cancer cell - 14 Dec 2020

Schuringa Jan Jacob, Bonifer Constanze

Abstract excerpt

Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Advanced biosensing and bioanalysis techniques
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Disease Progression

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 33321087
DOI: 10.1016/j.ccell.2020.11.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting Clonal Heterogeneity in AML.PMID 33321087Read ↗

Genetic heterogeneity and clonal evolution in acute myeloid leukemia.Semantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell GenomicsSemantic proximity Read ↗

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.Semantic proximity Read ↗

Clonal competition within complex evolutionary hierarchies shapes AML over time.Semantic proximity Read ↗

Single-cell mutation analysis of clonal evolution in myeloid malignancies.Semantic proximity Read ↗

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?Semantic proximity Read ↗

Single cell mutational profiling delineates clonal trajectories in myeloid malignanciesSemantic proximity Read ↗

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.Semantic proximity Read ↗

Genotype-immunophenotype relationships in NPM1-mutated AML clonal evolution uncovered by single-cell multiomic analysis.Semantic proximity Read ↗

Single cell analysis of clonal architecture in acute myeloid leukaemia.Semantic proximity Read ↗

Clonal Architecture and Evolutionary Dynamics in Acute Myeloid LeukemiasSemantic proximity Read ↗

Single-cell mutational profiling enhances the clinical evaluation of AML MRD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.