Article

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

2020-02-09

Abstract excerpt

<h4>Summary</h4> Myeloid malignancies, including acute myeloid leukemia (AML), arise from the proliferation and expansion of hematopoietic stem and progenitor cells which acquire somatic mutations. Bulk molecular profiling studies on patient samples have suggested that somatic mutations are obtained in a step-wise fashion, where mutant genes with high variant allele frequencies (VAFs) are proposed to occur early...

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Literature Corpus work: 3924b06f-dba1-58d8-95b2-7243f85dd877
DOI: 10.1101/2020.02.07.938860

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