Article
Genotype-immunophenotype relationships in NPM1-mutated AML clonal evolution uncovered by single-cell multiomic analysis.
Blood - 25 Jun 2026
Drucker Morgan, Lee Darren, Bowman Michael, Zhang Xuan, Kain Bailee N, Nicolet Deedra, Bandopadhyay Roopsha, Singh Varsha, Wang Zhe, Stone Richard M, Saygin Caner, Mrózek Krzysztof, Carroll Andrew J, Starczynowski Daniel T, Levine Ross L, Byrd John C, Salomonis Nathan, Skuli Sarah J, Grimes H Leighton, Eisfeld Ann-Kathrin, Bowman Robert L, Miles Linde A
Abstract excerpt
ABSTRACT: Acute myeloid leukemia (AML) is a multiclonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing cannot fully capture AML clonal architecture or the clonal evolution that occurs as patients undergo therapy. To interrogate clonal evolution, we performed simultaneous single-cell molecular profiling and...
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