Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia.

Science translational medicine - 1 Apr 2015

Paguirigan Amy L, Smith Jordan, Meshinchi Soheil, Carroll Martin, Maley Carlo, Radich Jerald P

Abstract excerpt

Clonal evolution in cancer-the selection for and emergence of increasingly malignant clones during progression and therapy, resulting in cancer metastasis and relapse-has been highlighted as an important phenomenon in the biology of leukemia and other cancers. Tracking mutant alleles to determine clonality from diagnosis to relapse or from primary site to metastases in a sensitive and quantitative manner is most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Artifacts
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Recurrence

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25834112
DOI: 10.1126/scitranslmed.aaa0763
PMCID: PMC4405099

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia.PMID 25834112Read ↗

Single cell mutational profiling delineates clonal trajectories in myeloid malignanciesSemantic proximity Read ↗

Genotype-immunophenotype relationships in <i>NPM1</i> -mutant AML clonal evolution uncovered by single cell multiomic analysisSemantic proximity Read ↗

Genotype-immunophenotype relationships in NPM1-mutated AML clonal evolution uncovered by single-cell multiomic analysis.Semantic proximity Read ↗

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.Semantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell GenomicsSemantic proximity Read ↗

Single-cell mutation analysis of clonal evolution in myeloid malignancies.Semantic proximity Read ↗

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.Semantic proximity Read ↗

Genetic heterogeneity and clonal evolution in acute myeloid leukemia.Semantic proximity Read ↗

Dissecting Clonal Heterogeneity in AML.Semantic proximity Read ↗

Single cell analysis of clonal architecture in acute myeloid leukaemia.Semantic proximity Read ↗

Single-cell mutational profiling and clonal phylogeny in cancer.Semantic proximity Read ↗

Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.