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Article

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia.

Science translational medicine - 1 Apr 2015

Paguirigan Amy L, Smith Jordan, Meshinchi Soheil, Carroll Martin, Maley Carlo, Radich Jerald P

Abstract excerpt

Clonal evolution in cancer-the selection for and emergence of increasingly malignant clones during progression and therapy, resulting in cancer metastasis and relapse-has been highlighted as an important phenomenon in the biology of leukemia and other cancers. Tracking mutant alleles to determine...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 25834112
DOI: 10.1126/scitranslmed.aaa0763
PMCID: PMC4405099

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25834112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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