Article
Resolving inter- and intra-patient heterogeneity in NPM1-mutated AML at single-cell resolution.
Leukemia - 1 Dec 2025
Karakaslar E Onur, Argiro Eva M, Struckman Nadine E, Shirali Hz Ramin, Severens Jeppe F, Honders M Willy, Kloet Susan L, Veelken Hendrik, Reinders Marcel Jt, Griffioen Marieke, van den Akker Erik B
Abstract excerpt
NPM1-mutated AML is one of the largest entities in international classification systems of myeloid neoplasms, which are based on integrating morphologic and clinical data with genomic data. Previous research, however, indicates that bulk transcriptomics-based subtyping may improve prognostication and therapy guidance. Here, we characterized the heterogeneity in NPM1-mutated AML by performing single-cell...
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