Article

Resolving inter- and intra-patient heterogeneity in<i>NPM1-</i>mutated AML at single-cell resolution

2024-12-11

Abstract excerpt

<h4>ABSTRACT</h4> NPM1- mutated AML is one of the largest entities in international classification systems of myeloid neoplasms, which are based on integrating morphologic and clinical data with genomic data. Previous research, however, indicates that bulk transcriptomics-based subtyping may improve prognostication and therapy guidance. Here, we characterized the heterogeneity in NPM1 -mutated AML by performing si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eab6b78c-d2a7-597a-8ef2-4db2a135cf36
DOI: 10.1101/2024.12.10.24317471

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resolving inter- and intra-patient heterogeneity in<i>NPM1-</i>mutated AML at single-cell resolutionDOI 10.1101/2024.12.10.24317471Read

Resolving inter- and intra-patient heterogeneity in NPM1-mutated AML at single-cell resolution.Semantic proximity Read

The cellular state space of AML unveils novel <i>NPM1</i> subtypes with distinct clinical outcomes and immune evasion propertiesSemantic proximity Read

Genotype-immunophenotype relationships in <i>NPM1</i> -mutant AML clonal evolution uncovered by single cell multiomic analysisSemantic proximity Read

Genotype-immunophenotype relationships in NPM1-mutated AML clonal evolution uncovered by single-cell multiomic analysis.Semantic proximity Read

Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responsesSemantic proximity Read

Mapping AML heterogeneity - multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses.Semantic proximity Read

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia.Semantic proximity Read

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AMLSemantic proximity Read

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.Semantic proximity Read

Characterization of The Heterogeneity of Bone Marrow in NK-AML (M4/M5) Based on Single Cell RNA SequencingSemantic proximity Read

Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencingSemantic proximity Read

Unveiling novel insights in acute myeloid leukemia through single-cell RNA sequencingSemantic proximity Read