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Article

Single cell analysis of clonal architecture in acute myeloid leukaemia.

Leukemia - 1 May 2019

Potter Nicola, Miraki-Moud Farideh, Ermini Luca, Titley Ian, Vijayaraghavan Gowri, Papaemmanuil Elli, Campbell Peter, Gribben John, Taussig David, Greaves Mel

Abstract excerpt

We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened for 111 mutations that are recurrent in AML and cancer. Clonal architectures were relatively simple with one to six sub-clones and were branching in some, but not all, patients. NPM1 mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 30568172
DOI: 10.1038/s41375-018-0319-2
PMCID: PMC6451634

Genes

CD33
NPM1
CD34
IDH2
TET2
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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